pentobarbital will reduce the level or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Pitolisant publicity is diminished by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will lower the level or impact of felodipine by affecting hepatic/intestinal enzyme CYP3A4 met